Barely Significant
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The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology.

PLoS One · 2012 · PMC3460820 · PMID 23029473

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highly significantno p-value reported
VCP is important in mediating protein degradation, a highly significant process for terminally differentiated cells.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.