Although increases in NHE activity were observed at all concentrations of ET-1 tested, with a greater than 2-fold increase in NHE activity at 10 nmol/L, the difference with 0.1 nmol/L ET-1 did not quite reach statistical significance.
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Endothelin-1 augments Na⁺/H⁺ exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase.
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