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Endothelin-1 augments Na⁺/H⁺ exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase.

PLoS One · 2012 · PMC3460862 · PMID 23029469

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Although increases in NHE activity were observed at all concentrations of ET-1 tested, with a greater than 2-fold increase in NHE activity at 10 nmol/L, the difference with 0.1 nmol/L ET-1 did not quite reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.