Prognostic utility of pre-operative circulating osteopontin, carbonic anhydrase IX and CRP in renal cell carcinoma.

Highly significant differences ( P <0.0001; Mann–Whitney) were seen between concentrations of these variables in patients with metastatic disease compared with localised disease ( Figure 1 ) with median values (IQR) respectively of 22.2 (4.2–111) vs 5.7 (0.6–11.5) mg l −1 for CRP, 189.2 (114.8–303.4) vs 82.3 (575.5–131.1) μ g l −1 for OPN and 186.4 (89.6–336.2) vs 102.5 (61.6–153.9) μ g l −1 for CA9.

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A recent larger study involving 361 RCC patients including 287 with clear cell histology found a positive trend between serum and tissue CA9 and a significant correlation between serum CA9 and stage but not grade.

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