Affective network At the whole brain level, we observed a statistical trend for a reduction in functional connectivity between the sgACC seed region and the right dorsal medial prefrontal cortex (DMPFC) following ketamine administration compared to placebo (n = 17, paired t-test: p uncorr <0.001, extent threshold of k>13, resulting in a cluster-level p corr <0.1; Fig. 4 ).
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Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action.
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