The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain.

Mol Brain · 2012 · PMC3462686 · PMID 22713619

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an increasing trendno p-value reported

On the other hand, although the change of NICD expression in the DRG was not statistically significant compared with the sciatic nerve and spinal cord, there was an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.