Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo.

In the initial steps of pathogenesis of melanoma the alterations in expression and activity of DPPIV might be significant: a) During malignant transformation of melanocytes into melanoma cells, down-regulation of DPPIV expression and later complete loss of expression occurs [ 13 , 14 , 17 ]; b) DPPIV gene is localized in chromosome 2q24.2, interestingly this chromosome is altered in 35% of melanoma specimens, indicati

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