Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.

Retrovirology · 2012 · PMC3464899 · PMID 22651890

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highly significantno p-value reported

Background HIV-1 Nef is a highly significant pathogenic factor, but its role in the progression to AIDS is not mechanistically understood.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.