Epidemiologic and molecular pathophysiology of chronic opioid dependence and the place of naltrexone extended-release formulations in its clinical management.

Subst Abuse · 2012 · PMC3465087 · PMID 23055738

Europe PMC DOI

hedged sentences

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closest p

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boldest claim

The sentences

highly significantno p-value reported

Opportunely, six recent clinical trial data from several continents have uniformly provided dramatic evidence of the potent, dose-related and highly significant efficacy of NI, with minimal or manageable accompanying toxicity and safety concerns.

also in 132,142 other papers

did not quite reach significanceno p-value reported

The reduction in cannabis craving in that study was P = 0.08, which did not quite reach significance.

also in 350 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.