Interval between Surgery and Radiation Therapy Is an Important Prognostic Factor in Treatment of Rectal Cancer.

In univariate analysis for identification of potential prognostic factors related to OS and DFS, TNM staging, PNI, LVI, and interval between surgery and radiation were statistically significant and the treatment modality was marginally significant ( Table 3 ). 5YDFS was 82.4% in stage I, 53.6% in stage II, and 28.6% in stage III. 5YDFS was 50.5% in patients for whom the interval between surgery and radiation was within five weeks, and 32.9% in those for whom the interval exceeded five weeks ( Figs. 2 and 3 ).

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