Results Correlation of TRX Score to Minor Groove Width Dimensions of DNA As expected, we found a strong and highly significant positive correlation between the minor groove widths (in angstroms) of tetramers observed in both free DNA structures and protein-bound DNA structures and their calculated sums of TRX scores ( r = 0.66, P < 0.0001, df = 193; fig. 1 B ) indicating a strong role of P linkage flexibility in determining DNA shape.
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Codons support the maintenance of intrinsic DNA polymer flexibility over evolutionary timescales.
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