Mechanism of growth inhibition of prostate cancer xenografts by valproic acid.

The DU145 xenografts also showed a similar trend in reduction of MVD from 31.28 ± 4.18/mm 2 to 25.25 ± 2.61/mm 2 but failed to reach significance ( P = 0.14). 3.2.

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Cyclin D1 levels decreased significantly in treated animals irrespective to tumor type ( Figure 1(b) and Table 1 ), while p27 KIP1 levels increased significantly in LNCAP and DU145 xenografts but failed to achieve significance in C4-2 xenografts ( Figure 1(b) and Table 1 ).

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