Functional haplotypes of the hTERT gene, leukocyte telomere length shortening, and the risk of peripheral arterial disease.

Of the risk factors measured, marginally significant inverse associations were found between telomere length and waist-hip ratio, serum total cholesterol, and LDL cholesterol, which indicated that longer telomeres corresponded with a better health status ( File S2 ). hTERT Gene Variants Predispose to Telomere Length Shortening and PAD Risk The frequencies of rs2735940 and rs2853669 in the hTERT gene did not deviate significantly from Hardy-Weinberg equilibrium in this case-control sample population (all P >0.05).

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