Cytochrome c oxidase-intermediate fibres: importance in understanding the pathogenesis and treatment of mitochondrial myopathy.

A highly significant difference in the wild type mtDNA copy number per μm 3 between COX-intermediate reacting and COX-normal muscle fibres ( P < 0.0003) and between COX-intermediate reacting and COX-deficient muscle fibres ( P < 0.0004) was noted, providing further evidence that wild-type mtDNA copy number is the criti

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