Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen.

As expected, Kaplan–Meier survival analyses showed highly significant differences in DRFS across the groups predicted to have good or intermediate or poor prognosis (PAM50-RORS, PAM50-RORP, GHI, ROT76 and NKI70) or the groups predicted to have high or intermediate versus low expression of ER-regulated genes (SET and IE-IIE).

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In node-positive disease, univariate DRFS analyses revealed that most signatures were barely significant when evaluated as continuous variables ( supplemental Figure S6 and Table S4 , available at Annals of Oncology online).

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When evaluated as group categories, low risk of relapse or high expression of ER-regulated gene groups showed either no statistical significance or borderline significance in terms of DRFS compared with the predicted poor prognostic or low expressers of ER-regulated gene groups.

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When limited to the microarray dataset, the PAM50-RORS and PAM50-RORP were trending toward significance ( supplemental Table S5 , available at Annals of Oncology online) and both were significant when the Nielsen series was included for a total of 280 luminal A patients ( supplemental Table S5 , available at Annals of Oncology online and PAM50-RORP in Figure 3 B).

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