Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments.

PLoS One · 2012 · PMC3479114 · PMID 23110044

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marginally statistically significantno p-value reported

The smaller force peak is marginally statistically significant for E1638K and L1657I and statistically significant for I1628T ( Figure 6e ), indicating that these type 2A mutations are likely to lower the force resistance of the protein at least in the initial stages of unfolding.

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