highly significantp < 0.001
The differences are significant: likelihood ratio tests for models of b t , including a random effect to capture mouse to mouse variation, and accounting for temporal autocorrelation (fitted with lme in the nlme package in R) reveal a highly significant interaction between ‘day’ and ‘clone’ (likelihood ratio test: χ 2 = 2410, d.f. = 119, p < 0.001).