Histopathologic investigation of the effects of prostaglandin E2 administered by different methods on tooth movement and bone metabolism.

In particular, the differences between the negative control and the positive control, intravenous PGE2, and intraligamentous PGE2 groups were highly significant ( p < 0.001), while the difference between the negative control and the submucosal PGE2 groups was less pronounced ( p < 0.05).

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