Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.

Profile-profile comparisons using an alignment of the Het-C domain (Figure 8 E) revealed hits with borderline significance (p = .001; 50% probability) to a group of α-helical hydrolases sharing a common a fold, including zinc-dependent phospholipase C [ 131 ] and the S1-P1 nucleases [ 132 ].

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