It was show that adenovirus (AdV)-mediated IL-24 overexpression exerted potent antitumor activity via stimulating mitochondrial apoptotic pathway in GBC-SD, and that mda-7/IL-24 has the potential to serve as a tool for targeted gene therapy in the treatment of GBC.[ 35 ] Moreover, the haplotype 1/C of IL-1RN and IL-1B was found to confer a significantly enhanced risk of GBC in cancer patients with gallstones, while higher risk resulting from 2/C haplotype was of borderline significance.
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Molecular biology of gallbladder cancer: potential clinical implications.
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