Increased cellular immune responses and CD4+ T-cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus - simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques.

Pearson coefficient of determination analysis of these independent measures showed a highly significant inverse correlation of the proliferating CD4+Ki67+ T-cells and plasma viremia, regardless of treatment or timepoint (Figure 3 ).

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The result of clinical trial in Thailand testing with various subtype B canarypox-HIV-1 recombinant vaccine candidates and boosters containing subunit glycoprotein 120 or 160 did not generate strong cellular or detectable neutralizing antibody responses to HIV-1 yet showed marginally significant protection from infection [ 4 ].

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