Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies.

After adjusting by single years of age and other potential confounding factors, the heterogeneity at ages 45–54 years between premenopausal and postmenopausal women is highly significant both for oestrogen receptor status (heterogeneity p=0·003) and for tumour histology (heterogeneity p<0·0001, appendix p 11 ).

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