Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.

Nucleic Acids Res · 2012 · PMC3488249 · PMID 22941664

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highly significantno p-value reported

To focus on essential functions, we browsed annotations for 1203 genes (16% of a non-redundant gene set) that displayed a highly significant loss-of-fitness ( z -score > 5) in the BF T1 RIT-seq screen, involving knockdown in bloodstream-form cells for 3 days ( 15 ).

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