highly significantP < 2.2 × 10 −16
We found that both up- and downregulated genes showed highly significant enrichment for association signals ( Z = 9.41, P < 2.2 × 10 −16 for genes downregulated by SUMO-1 depletion and Z = 3.43, P = 4.19 × 10 −4 for genes upregulated by SUMO-1 depletion; Figure 5 D).