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Remote ischemic preconditioning (RIPC) modifies plasma proteome in humans.

PLoS One · 2012 · PMC3489679 · PMID 23139772

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an overall trendno p-value reported
There was an overall trend of up-regulation of protein expression in blood taken from the transiently ischemic limb during the RIPC protocol and this increase in the number of up-regulated peptides was cumulative with each cycle of the IR of the limb.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.