The A736V TMPRSS6 polymorphism influences hepatic iron overload in nonalcoholic fatty liver disease.

Notwithstanding, in the overall series of patients the negative association (with borderline significance) between the p.736Val variant and the presence of detectable hepatic iron was paralleled by decreased levels of hepatocellular ballooning, a typical manifestation of oxidative stress in NAFLD [52] , which is possibly related to iron status.

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There was a nonsignificant trend for an increased prevalence of the p.Cys282Tyr HFE mutations in patients, whereas the prevalence of the beta-thalassemia trait was significantly higher in patients than in controls, but it represented and exclusion criterium for the control group.

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