Barely Significant
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Molecular epidemiology, antimicrobial susceptibilities and resistance mechanisms of Streptococcus pyogenes isolates resistant to erythromycin and tetracycline in Spain (1994-2006).

BMC Microbiol · 2012 · PMC3490898 · PMID 22998619

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an increasing trendno p-value reported
In this last report, flutuations in the rates of resistance to macrolides are observed (1996–1997: 26.7%; 1998–1999: 20.4%; 2001–2002: 24.3; 2006–2007: 19%) meanwhile there is an increasing trend in the prevalence of MLS B phenotype from 14% in 2001–2002 to 35.5% in 2006–2007 [ 17 ].

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