RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice.

As shown in Table 1 , we found highly significant overlap among genes with >3-fold differential expression in aged mice treated with rhTFAM and 19 GO families differentially expressed in aged compared to young adult brains. 15 of these GO families relate to developmental and morphogenesis gene families; 4 relate to DNA binding and transcription factor activities.

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