Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.

There was a highly significant positive correlation between hepatic cellular infiltrates and the copy number of dnTGFβRII transgene (r = 0.9342, p<0.0001), indicating that abrogation of TGFβ signaling by higher copy number of dnTGFβRII contributes to the emergence of T cell lymphoma-like T cell infiltration.

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