Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro.

PLoS One · 2012 · PMC3492287 · PMID 23145164

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fairly significantno p-value reported

This could be attributed to the fact that the pKa of daunorubicin is slightly higher than the pKa of mitoxantrone and that relatively minor changes in pKa can translate into fairly significant increases in IDB selectivity.

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