Imaging data do not allow us to distinguish confidently between mitochondrial Ca 2+ accumulation and a discrete ‘late’ Ca 2+ influx at the midpiece, but it may be significant that 5 μM 2-APB is reported to slow the export of Ca 2+ from mitochondria [ 46 ].
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2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm.
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