Evaluation of the predilution technique in reducing the occurrence of bleeding during continuous venovenous haemofiltration in critically ill patients. Efficacy of predilution in reducing the amount of anticoagulation during CVVH

• Symptomatic bleeding happened in one patient in the predilution group and in four patients in the post-dilution one ( P < 0.05, highly significant). • The median amount of heparin used in the predilution group was about 450 U/h and 750 U/h in the post-dilution group ( P < 0.05, highly significant). • The median filter efficiency was 32.3 h for the predilution group and 33.9 for the post-dilution group ( P > 0.05, no statistical difference).

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