Effectiveness and harms of seasonal and pandemic influenza vaccines in children, adults and elderly: a critical review and re-analysis of 15 meta-analyses.

Hum Vaccin Immunother · 2012 · PMC3495721 · PMID 22777099

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an interesting trendno p-value reported

S8 and S9 ), but an interesting trend over time was observed for PIV: the efficacy tended to decrease with time, and the meta-analysis restricted to the five RCTs published in the last decade failed to show a significant protection of PIV (efficacy 9%; 95% CI: -9%; 23% –Fig. 8).

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