Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma.

A comprehensive CPH model including all significant covariates along with GP88 was also performed to determine whether GP88 remained highly significant even when adjusted for other risk factors simultaneously.

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The results of Table 5 show that there was a marginally significant interaction of GP88 with tumor size in DFS, but no hint of interaction between GP88 and any of the other indicators investigated, such as tumor grade, lymph node status, disease stage, PR expression, age, ethnicity and treatments.

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