Barely Significant
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This Déjà vu feeling--analysis of multidomain protein evolution in eukaryotic genomes.

PLoS Comput Biol · 2012 · PMC3499355 · PMID 23166479

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a decreasing trendno p-value reported
The number of distinct domains per genomes shows little variance between different organisms (with the exception of some parasitic species) and, when including inferred sets for the ancestral species, generally displays a decreasing trend in going from the last common eukaryotic ancestor to large multicellular organisms [5] .

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