Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

Six-week post-MI, all animals had highly significant LV hypertrophy, dilatation, and dysfunction compared with the baseline, consistent with the development of CHF, but there were no significant differences between WT and CrT-OE mice, and no relationship between LV creatine and ejection fraction (triangles Figure 1 B–F ).

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