Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose.

Overexpression of G6PD also led to a trend to rescuing of glutathione reductase (GR) and superoxide dismutase (SOD) activity that did not quite reach statistical significance (data not shown) and no change in GR or SOD protein levels ( Figure S2 and S3 ).

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