Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents.

Incubation with TBHP also induced a rise in the lipid peroxide content of both control INS-1 cells (2.20 ± 0.09-fold) and in iPLA 2 γ -KD cells (2.56 ± 0.15-fold), and there was a nonsignificant trend for the level achieved in the latter (0.86 ± 0.05 pmol/ μ g) to exceed that in the former (0.74 ± 0.03 pmol/ μ g). 3.5.

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