In case of macrometastatic disease, there was a nonsignificant trend toward better outcomes in axillary recurrences and survival after cALND, but only after analysis was adjusted for clinicopathologic differences. 10 In the ACOSOG Z0011 trial, Giuliano et al. 65 observed no differences in overall survival between the cALND arm and the arm in which cALND was not performed.
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Axillary recurrence after a tumor-positive sentinel lymph node biopsy without axillary treatment: a review of the literature.
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