Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis.

As already discussed, patient characteristics, particularly in regard to BMI and the prevalence of diabetes, may be significant sources of heterogeneity when comparing the prevalence of steatohepatitis between studies. 36 In the studies of Gomez-Ramirez et al. 30 and Pawlik et al., 31 both of which reported a positive association between steatohepatitis and irinotecan, patients receiving irinotecan were more likely to have a higher mean BMI (29.3 vs. 26.2 and 28.1 vs. 26.6 kg/m 2 , respectively).

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