Metformin and the risk of cancer: time-related biases in observational studies.

Diabetes Care · 2012 · PMC3507580 · PMID 23173135

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highly significantno p-value reported

Two meta-analyses including some of these observational studies reported a highly significant reduction in cancer incidence or mortality associated with metformin use (risk reductions ranged between 31 and 34%) ( 9 , 10 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.