The biological processes related to enriched GO categories (n = 1,110) included positive regulation of the following pathways: cell migration; heart, kidney and mammary gland development; angiogenesis; ion transport; skeletal system and muscle organ development; calcium homeostasis and metabolism; regulation of MAPK-, BMP, SMAD-, Wnt-, and Rho protein signaling; wound healing; glycogen biosynthesis; blood vessel morphogenesis; lipid metabolism; regulation of mitotic cell cycle; protein ubiquitination; immune response and multiple others, all highly significant, indicating that DOX cardiotoxicity and DOX cytotoxicity are both multifactorial processes.
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Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model.
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