Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.

Further, in Cox proportional hazard models that take into account VL, the HR remained high (2.18 and 3.12 respectively) and p values continued to trend or remain borderline significant (p = 0.093 and 0.051) ( Table 2 ), indicating that both VL and RC can independently affect CD4 loss.

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Indeed, when host factors known to modulate VL such as the presence of protective or unfavorable HLA-I alleles, gender, age, and HLA-B sharing are taken into account in a multivariable analysis utilizing a general linearized model, the correlation between donor and recipient VL becomes highly significant (Yue et al. , manuscript in submission).

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