Enzymatically produced pools of canonical and Dicer-substrate siRNA molecules display comparable gene silencing and antiviral activities against herpes simplex virus.

As expected, we observed strong activation of IFN-β , IFN-λ1 and ISG54 genes in response to 88-bp dsRNA with highly significant (p<0.01) difference compared to all other treatments in both HaCaT and U373MG cell lines at almost all time points ( Figure 2 ).

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