A randomized prospective study of desflurane versus isoflurane in minimal flow anesthesia using "equilibration time" as the change-over point to minimal flow.

J Anaesthesiol Clin Pharmacol · 2012 · PMC3511943 · PMID 23225926

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a decreasing trendno p-value reported

an increasing trendno p-value reported

Similar findings were obtained by others.[ 2 ] In the earlier studies, change over from high to low FGF was done after 10–20 min, as recommended by Baum.[ 2 , 9 , 10 ] In minimal flow anesthesia, nitrous oxide usually shows an increasing trend while oxygen shows a decreasing trend because nitrous oxide is neither consumed nor metabolized, but oxygen is consumed by the body.

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