highly significantP = 0.0009
167 A highly significant association was found between carriage of the rarer allele at IL-1A (+4845) and response to treatment (OR = 4.8; 95% CI: 1.8–12.7; P = 0.0009). 167 Moreover, the response rate in patients carrying this allele was 63.4% compared with 26.3% in noncarriers. 167 Due to the paucity of pharmacogenetic data on IL-1 receptor antagonists and other biologics (eg, IL-12/23 variants) in RA patients, much more research is warranted to better define the relationship between the IL-1 gene cluster and response to IL-1 receptor antagonists.