33 In addition to examining the effects of CYP3A4 on surrogate markers, an observational case-control study involving 186 patients receiving clopidogrel for ACS found only a trend toward significance of an association between the presence of a CYP3A4 polymorphism and the occurrence of a repeat cardiovascular event while receiving clopidogrel (16.8% vs 9.6%, P = 0.052). 34 CYP3A5 A multivariate analysis of 348 patients treated with clopidogrel after planned stent placement investigated the effect of a CYP3A5 polymorphism on the risk of atherothrombotic events at one and six months post-procedure. 35 The study identified CYP3A5 polymorphisms as an independent predictor of atherothrombotic events at six months follow-up.
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