Thirteen of 17 studies reported that low ERCC1 correlated with better clinical outcome (total n = 1815), 77 – 85 , 87 , 91 , 92 or had a statistical trend towards better outcome (total n = 218). 38 Two studies showed no correlation between ERCC1 level and outcome (n = 218), 89 , 90 while two studies showed a significantly worse outcome (total n = 269) 27 , 88 in patients with tumors expressing low levels of ERCC1.
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