Interactive association of five candidate polymorphisms in Apelin/APJ pathway with coronary artery disease among Chinese hypertensive patients.

Interestingly and consistently, rs3761581 from the best overall model in males conferred a marginally significant role on the development of CAD (OR = 0.77; 95% CI: 0.57–1.02; P = 0.072) after adjusting for age, type 2 diabetes mellitus, BMI and SBP, and in females, interaction probability of rs7119375 and rs9943582 from the best overall model reached statistical significance (OR = 0.88; 95% CI: 0.81–0.95; P = 0.02), these findings further validating that from MDR method.

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For haplotype A-G in apelin gene with marginal significance in prediction of CAD, the power to reject the null hypothesis of no difference in frequencies between patients and controls was 71.8%.

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