When we analyze the APL1 paralogs separately, we find that APL1C , the only APL1 paralog involved in the described protein complex, is a clear outlier from the majority of loci in this population ( Figure 3 ), although its HEW statistic is marginally nonsignificant after multiple testing ( HEW corrected p = 0.084).
Our previous studies showed a highly significant association between microsatellite (H603) alleles inside an intron of DLL and infection by P. falciparum ( Niaré et al. 2002 ; Riehle et al. 2006 ), and the signal identified here may reflect linked selection on the functional site driving these signals, although the genetic mapping was conducted in the M and S molecular forms while the signal detected here came from GOUNDRY, where such mapping has not yet been done.