Hepatitis B- and hepatitis C-related hepatocellular carcinomas in the United States: similarities and differences.

To explain these findings, Huitzil-Melendez et al postulates that there may be significant differential expression of Raf-1, an important kinase involved in the oncogenesis of HCC, among HCV- and HBV-related HCC, given that HCV core proteins are known to induce a high basal rate of Raf-1 activity ( 50 , 51 ).

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